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About Inheritable Genetic Modification


The Basic Science

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



What Good is a Scientific Meeting If You Dismiss the Science?by Jessica CussinsBiopolitical TimesOctober 29th, 2014The Science and Technology Committee of the UK Parliament held an evidence hearing last week to examine the science and proposed regulation of so-called “mitochondrial donation,” or “3-person IVF,” but huge swaths of evidence were widely dismissed.
Minister Sparks Backlash for Suggesting Foreigners Could Undergo 'Three-Parent Babies' IVF Treatment in Britainby Ben Riley-SmithTelegraphOctober 23rd, 2014MPs and peers from across the political divide raised fears the move could create a new front of health tourism, with foreigners coming to the UK to circumvent bans in their home countries.
Bid to Delay ‘Three Parent Babies’ Through IVF as Tests Find Fears Could Suffer Reduced Fertility, Learning Difficulties and even Cancerby Jonathan Petre and Stephen AdamsMail on SundayOctober 4th, 2014Legislation to allow the birth of babies with genes from three biological parents should be put on hold because it is far riskier than previously thought, scientists warn.
The Collapse of a Dangerous Analogy: Or, why mitochondria are much more than batteries by Jessica CussinsBiopolitical TimesSeptember 29th, 2014Amid a flood of new evidence that mitochondria impact an individual’s traits, the editors at New Scientist have made a “U-turn” on “three-parent babies.” Their new conclusion: “It’s more messy than we thought.”
Three-Parent Babies: It's More Messy Than we Thoughtby EditorialNew ScientistSeptember 18th, 2014It appears that we may have seriously underestimated the influence that mitochondria have. Recent research suggests that they play a key role in some of the most important features of human life.
New Poll Finds Only 18% of British Adults in Support of "3-Person IVF"by Jessica CussinsBiopolitcal TimesSeptember 15th, 2014A newly released poll finds substantial public reluctance to change UK law to allow the genetic modification of future generations.
“Evolution right now is in the marketplace”by Pete ShanksBiopolitical TimesSeptember 11th, 2014George Church is as outrageous as ever, while both transhumanist ideas and concerns about increasing inequality are receiving more attention.
A Manifesto for Playing God with Human Evolutionby Carl ElliottNew ScientistSeptember 8th, 2014Fancy living forever, or uploading your mind to the net? The Proactionary Imperative embraces transhumanist dreams, but reminds why we need medical ethics.
Myth Replacement Therapy: MPs Debate the Science of Mitochondriaby Dr Ted MorrowBioNewsSeptember 8th, 2014There are clearly misconceptions about mitochondrial genetics repeated during the debate that are not supported by current scientific evidence.
Editing DNA Could be Genetic Medicine Breakthrough[References CGS]by Stephanie M. LeeSan Francisco ChronicleSeptember 7th, 2014A new way to make powerful changes at will to the DNA of humans, other animals and plants, much like how a writer changes words in a story, could usher in a transformation in genetic medicine.
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