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About Inheritable Genetic Modification


The Basic Science

Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Staying Ahead of Technology’s Curvesby Doug HillBoston GlobeAugust 21st, 2016Embracing new technologies with extraordinary disruptive powers without trying to anticipate and prepare for their potential consequences is now, more than ever, a bad idea.
In CRISPR Fight, Co-Inventor Says Broad Institute Misled Patent Officeby Antonio RegaladoMIT Technology ReviewIs an email between competing researchers a smoking gun in the billion dollar battle over patent rights for gene editing?
In the Fight for Our Genes, Could We Lose What Makes Us Human?by Ziyaad BhoratopenDemocracyAugust 17th, 2016The rapid commercialization of genetics threatens human dignity as our biology is exposed to society's political economy.
What happens when anyone can edit genes at home? We’re about to find outby Dyllan FurnessDigital TrendsAugust 15th, 2016Scientists express concern about the unintentional consequences of gene editing starter kits proliferating in biohacking communities.
Public policy must address technology’s impact[citing CGS' Marcy Darnovsky]by John M. HeinThe Sacramento BeeAugust 13th, 2016“We need to develop habits of mind, or habits of social interaction, that will allow for some very robust public participation on the use of these powerful technologies,” says Marcy Darnovsky.
Scientists break 13-year silence to insist 'three-parent baby' technique is safeby Ian JohnstonThe IndependentAugust 11th, 2016The researchers conclude the technique "can produce a viable pregnancy." But the pregnancy they established resulted in miscarriage.
Diversity, disability and eugenics: An interview with Rob Sparrowby Xavier SymonsBioEdgeAugust 11th, 2016Philosophers and the medical profession have been way too swift to make judgments about other people’s quality of life. We're not as far from the bad old eugenics as many think.
Human Gene Editing: A Timeline of CRISPR Cover StoriesWith recent gene editing tools, a number of high-profile media are featuring CRISPR on their covers and front pages. We gather highlights since early 2015, along with opinion polls, TV shows, and editorial board statements.
To Err is Biotechnological: Reflections on Pew’s Human Enhancement Surveyby Gina Maranto, Biopolitical Times guest contributorAugust 9th, 2016Biotechnologies aimed at human enhancement come with a guaranteed set of deficits, inadequacies, inconveniences, and risks.
Mind your genes! The dark legacy of eugenics lives onby Natasha MillerABC [Australia]August 8th, 2016The misguided science of behavioral genetics and the social engineering potential of CRISPR show we have much to remember about the history of eugenics.
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