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About Sequencing & Genomics


An organism's genome refers to all the hereditary information encoded in its genes. Sequencing a complete genome, a gene, or a fragment of genetic material involves determining the order of its sub-units: adenine, cytosine, guanine, and thymine.

Scientists are using individuals' genetic sequences to map and catalog human genetic variation in order to improve understanding of human biology, disease susceptibility, and drug response. As costs falls rapidly, the scale and speed of gene sequencing is increasing. The Human Genome Project required thirteen years and $3 billion to sequence the first complete, general human genome. Subsequent projects, such as the International HapMap Project, examined genetic variation between population groups, raising concerns of giving undue biological significance to social categories of race.

Now, the sequencing of complete genomes of specific individuals is becoming almost routine. For example, the Personal Genome Project plans to sequence 100,000 genomes.

Lower prices have also opened the door to companies that offer personal, direct-to-consumer genetic tests.


They’re going to CRISPR people. What could possibly go wrong?by Sharon BegleySTATJune 23rd, 2016Possible consequences range from off-target alterations to conflicts of interest in the clinical trial.
Stem Cells: Where Science, Hope and Hype Meetby Danielle VentonKQED NewsJune 22nd, 2016‘People always say, ‘You promised us cures, where are they now?' - Kevin McCormack
23andMe Sells Data for Drug Searchby Antonio RegaladoMIT Technology ReviewJune 21st, 2016The consumer genetic-testing startup has amassed one of the world’s largest databases of DNA.
Federal Oversight Group Has Complaints But Says Yes To CRISPR Trialby Alex LashXconomyJune 21st, 2016Concerns arise over consent forms and financial barriers to the CRISPR trial.
Money Behind First CRISPR Test? It’s from Internet Billionaire Sean Parkerby Antonio RegaladoMIT Technology ReviewJune 20th, 2016A next wave of cancer treatment trials to combine gene editing and immunotherapy.
Genetically enhancing our children could raise interest ratesby James D. MillerBusiness InsiderJune 19th, 2016Should researchers develop technology to genetically decipher and alter intelligence, individuals and the state would borrow more and save less.
First Human Test of CRISPR Proposedby Antonio RegaladoMIT Technology ReviewJune 16th, 2016Researchers propose using CRISPR/Cas9 to alter gene sequences associated with certain illnesses, such as some forms of cancer.
How iPS cells changed the worldby Megan ScudellariNatureJune 15th, 2016Induced pluripotent stem cells have become a potentially helpful method of personalized therapy.
Gene drive debate must include voices from Africa, elsewhereby Richard Nchabi KamwiSTATJune 15th, 2016Those countries most affected by malaria and other illnesses will be most affected by gene drive technologies.
Should We Sequence the DNA of Every Cancer Patient?by Antonio RegaladoMIT Technology ReviewJune 14th, 2016To match cancer patients with drugs, Strata Oncology plans to offer free genetic tests.
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