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About Inheritable Genetic Modification


The Basic Science

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Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



With World Watching, UK Allows Experiments to Genetically Alter Babiesby Jessica CussinsBiopolitical TimesMarch 4th, 2015Despite several possibly insurmountable legal and safety hurdles, the House of Lords gave the final approval needed to move into fertility clinics the embryo modification techniques referred to as “mitochondrial donation.”
Babies from Two Bio-Dads?by Pete ShanksBiopolitical TimesRecent research on human germ cells has revived speculation about the possible uses of artificial gametes.
Three-Parent IVF: What's The Hurry?[Quotes CGS's Marcy Darnovsky]by John FarrellForbesFebruary 28th, 2015Science shouldn’t be a rush order, especially when the health and well-being of a future generation and its descendants depends on it.
Reproduction 3.0by Leah RamsayBerman Institute of Bioethics BulletinFebruary 26th, 2015Bioethics scholars discuss the science and ethics of the UK vote to allow mitochondrial manipulation procedures.
Mitochondrial Gene Therapy Passes Final U.K. Vote[Quotes CGS's Marcy Darnovsky]by Gretchen VogelScience InsiderFebruary 24th, 2015The technique is controversial because the modified DNA would be passed on to future generations.
The Truth about Mitochondrial Replacementby Françoise BaylisImpact EthicsFebruary 23rd, 2015If we are to have honest conversation about possible benefits and harms of mitochondrial replacement, we should start by acknowledging that discussions to date have been a distraction.
Blog: Three Parent IVFby Dr Trevor StammersSt Mary’s University BlogFebruary 16th, 2015At our current stage of understanding of the interactions between mitochondrial and nuclear DNA, this proposed new therapy could turn out to be a monstrous mistake.
Three Parent Babies: Unethical, Unnecessary, Unsafe by Philippa TaylorBioNewsFebruary 16th, 2015The risks these new experiments hold for the lives and health of human embryos, children and egg donors, and the unprecedented modification of the human germline, together provide a case for not crossing this Rubicon.
Mitochondrial Mission Creep and the Cloning Connection by Pete ShanksBiopolitical TimesFebruary 14th, 2015Shoukhrat Mitalipov wants to use nuclear genome transfer for age-related infertility. He has joined forces with the disgraced stem cell researcher Hwang Woo-suk.
ADF to European Parliament: UK ‘Three-Parent Embryo’ Legislation IllegalGlobal DispatchFebruary 13th, 2015Couples can be helped without tampering with the building blocks of humanity. The issue comes down to fundamental human rights and the constitutional traditions of the member states.
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